En 1918, un barco llega al puerto de Río de Janeiro. Al interior se ha desatado una enfermedad. Hay muertos y mutilados, y los únicos sobrevivientes son un grupo de médicos. Las autoridades deciden dejarlos encerrados y los ven morir de hambre. Pero uno de ellos escapa y luego de perder a su familia, encuentra refugio en el Morro, donde tratará de encontrar una cura, usando a los habitantes pobres de la favela como conejillos de indias.
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